 研究的设计和分析 Primary endpoints
Duration of patient follow-up (date of ablation to last known chest CT or PET/CT)
Primary and secondary technical success rate
Time to first recurrence/local control rate
All-cause and cancer specific mortality
Immediate and delayed complications
Pneumothorax, hospital admission, pain, infection, acute respiratory distress syndrome (ARDS), bronchopleural fistula (BPF), and post-ablation syndrome
Patient Demographics
- November 2003 – March 2013
- Eligibility: solitary parenchymal mass treated for local control
- 108 patients (42 female, 66 male, mean age 72.5 ± SD 10.3) underwent MWA for a single lung malignancy under CT guidance
- All patients deemed medically inoperable (n=105) or refused surgery (n=3)
- 108 tumors
82 primary lung cancers
24 metastases (9 colorectal, 2 renal cell carcinoma, 2 sarcoma, 9 other)
- Mean tumor diameter of 3 cm
Local Control
Median duration of imaging follow up = 14.1 months [10,17]
-55% at 1 yr, 24 % at 2 yrs, and 12% at 3 yrs
Median time to local recurrence for technical success = 39.7 months [20, na]
Local control 75% at 1 yr, 59% at 2 yrs, and 40% at 40 months
here was a significant difference (p=0.002) in the recurrence rate for size >3 cm (17.6 months [6.6, na]) and <3 cm (62.1 months [28.9, na]).
 Survival for all patients
Median all-cause time to death for all patients = 27.1 months [20, 40.5]
78% at 1 yr, 54% at 2 yrs, 39% at 35 months
Median cancer-specific time to death for all patients = 42.2 months [33,na]
88% at 1 yr, 75% at 2 yrs, 60% at 41 months
All-cause Mortality
Cancer-specific Mortality
 
- For patients that achieved technical success, there was a significant difference (p=0.004) in cancer related survival for tumor size >3 cm (40.9 months [18.9, na]) vs. <3 cm (60.3 months [32.9, na])
- The difference in all-cause survival approached significance (p=0.06), with a median time to death for tumor size >3 cm of 20.3 months [13.6, 40.9] vs. <3 cm of 33 months [24.5, 60.3].
All-cause Mortality 
Cancer-specific Mortality
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