RFA (or TACE) + Anti-CTLA4 Checkpoint Inhibitor for HCC
12/14 HCV Reduced viral load Reduced AFP，6 week biopsy: CD8 up only if response 57% PFS @ 6 mo – heavily pre-treated pts
消融和Anti-CTLA4后远处肿瘤的镜下表现
Can see pseudoprogression on CT / MRI as a result of an immunologic infiltrate，More robust T cell infiltration in responders
 Greten & Duffy ASCO 2015, ASCO GI 2016, J Heptology 2016
Antigen Presentation at Margin of RFA
RFA plus DC CD11C IF staining
荧光显微镜下可见CD11c抗原提呈细胞(DC)在射频消融、ITDC和联合治疗后用FITC标记的CD11c抗体进行免疫组化检测。治疗后11天，取肿瘤，纵向分离，进行免疫组织化学分析。抗原提呈细胞(绿色)，用4‘，6-二胺-2-苯基吲哚(蓝色)染色.对照组肿瘤中抗原提呈细胞较少。相反，射频消融、ITDC和联合治疗的肿瘤CD11c染色水平均较高，提示治疗可增强肿瘤的DC浸润。
Dromi et al. Radiology 2009; 251: 58-66 |
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