SBRT 体部立体定向放疗_杨宁肿瘤介入医学网

SBRT Stereotactic Body Radiotherapy 体部立体定向放疗

http://www.morsecyberknife.com/procedure-cyberberknife.htm

Accuray “Cyberknife” XRay based SBRT

Trilogy-Cone Beam-CT based SBRT

Stereotactic Body RadiotherapyCentral Higher Risk Zone


entral zone may have higher toxicity due to risk of delayed bronchial stenosis and pulmonary artery injury

SBRT NSCLC Operable / Inoperable

Author	# of pts T1 vs T2	Local failure	Survival
Onishi et al J Thorac Oncol 2007 158 inoperable 99 operable All path proven pre SBRT	257 total	15%	OS 47% 5 yr 70.8% for >100Gy BED
	164 1A	8.4 % for >100 Gy BED【1】
	93 1B	8.4 % for >100 Gy BED【1】
Lagerwaard et al IJROPB 2008 167 inoperable 39 operable 31% path proven pre SBRT	219 total 129 T1 90 T2	3.5%	OS 64% 2 yr
Fakiris et al IJROPB 2009 All inoperable All path proven pre SBRT	70 total 34 T1 36 T2	5.7%	OS 42.7% 3 yr
Baumann et al J Clin Oncol 2009 66% path proven pre SBRT 53 inoperable 4 operable	57 total 40 T1 17 T2	8% in all T2 tumors	OS 60% 3 yr
Timmerman et al RTOG 0236 ASTRO November 2009 All inoperable All path proven pre SBRT	55 total 44 T1 11 T2	2% at 2 yrs	OS 72% 2 yr

【1】生物等效剂量

SBRT 体部立体定向放疗