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肺癌射频消融:三维适形放疗 vs 射频消融

时间:2020-03-03 16:52来源:未知 作者:admin
Medically Inoperable Stage I NSCLC: RF Ablation vs 3D-CRT Treatment, study, year Survival 1yr 2yr 3yr RF Ablation, RAPTUREclincal trial 2007 Overall survival 71% NA Cancer-specific survival 92% 92% NA 3D-CRT, Bradley et al, IJROBP 2003 Ove
Medically Inoperable Stage I NSCLC: RF Ablation vs 3D-CRT


  Treatment, study, year Survival
1yr 2yr 3yr
RF Ablation, RAPTUREclincal trial  2007      
Overall survival 71%   NA
Cancer-specific survival
92%
92% NA
3D-CRT, Bradley et al, IJROBP 2003      
Overall survival  73% 51% 34%
Cancer-specific survival 82% 67% 51%
Medically Inoperable Stage I NSCLC   RF Ablation vs SBRT
  2yr Survival
RF Ablation Stage IA and IB 
Overall survival
- sicker cohort c/w many SBRT series
- smaller series
48-80%
SBRT Stage IA and IB
Overall survival
62-72%


HIGH RISK Stage I NSCLC: XRT vs RFA in Medically Inoperable

  5-year OS
3D Conf XRT 10%~30%
RFA 30%~50%
 
RFA vs Radiation What about Recurrences?
- Local recurrences with RFA can be retreated with RFA or XRT
- Local Recurrences with XRT not easily retreated with XRT but can be treated with RFA

Recurrence after RFA Brown university Experience
To review the recurrence patterns in patients with primary non-small cell lung cancer (NSCLC) treated with percutaneous image-guided radiofrequency (RF) ablation.


The most common pattern of recurrence was local, which suggests that more aggressive initial RF ablation and adjuvant radiation may offer improvement in outcomes. Continued follow-up imaging is needed because new recurrences were seen throughout the 2 years following treatment.

在所有复发类型中,局部复发占比28%,是通过加强首次射频消融或配合辅助放疗,加强CT随访,因为新复发通常贯穿2年时间

Michael D Beland  Primary Non-Small Cell Lung Cancer: Review of Frequency, Location, and Time of Recurrence After Radiofrequency Ablation Radiology  254 (1), 301-7 2010(free)

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