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I期 NSCLC 射频消融结果

时间:2020-02-28 21:23来源:未知 作者:admin 点击:
RF Ablation Results Pulmonary RFA: Long-term safety and efficacy in 153 patients1 - Local control group (n = 132) - 71 patients with stage I NSCLC - Overall survival rates: stage I NSCLC 78% 57% 36% 27% 27% 1-year 2-year 3-year 4-year 5-ye
RF Ablation Results


Pulmonary RFA: Long-term safety and efficacy in 153 patients1 
 
- Local control group (n = 132)
        - 71 patients with stage I NSCLC
 
- Overall survival rates: stage I NSCLC
 

78%

57%

36%

27%

27%

1-year

2-year

3-year

4-year

5-year




Median time to death = 29 months 95% CI: 20 - 38 months
 
- Local tumor progression-free rates: ≤ 3 cm vs. > 3 cm





≤3cm

83%

64%

57%

47%

47%

 

1-year

2-year

3-year

4-year

5-year

>3cm

45%

25%

25%

25%

25%

≤ 3 cm: Median time to progression = 45 months
> 3 cm: Median time to progression = 12 months

 


RF Ablation Results: Comparative Therapies

Modality

5-year survival

Stage I NSCLC

Local Recurrence

(most within 2 years)

Lobar resection

60-80% 能手术尽手术

6.4% 

Sub-lobar resection

60-70%

17.2%

Image-guided ablation

27%

22.2%1

External beam radiation

5-20% 外照射I期不好?

50-55% 

1Chan et al. J Thorac Imaging 2011; 26:18-26.



RF Ablation Results: Comparative Therapies

Modality

5-year survival

Stage I NSCLC

Local Recurrence

(most within 2 years)

Image-guided ablation

27%

22.2%

Stereotactic radiotherapy1

54%

能放疗尽放疗

4% 

 

Stereotactic radiotherapy2

≤ 20 mm 89.8%

> 20 mm 53.1%

3.4% 

5.3%

1Uematsu et al. Int J Radiat Oncol Biol Phys 2008; 72(1):supplement s37. 
2Inoue et al. Int J Radiat Oncol Biol Phys 2009 Feb 19.


RF Ablation Results: Comparative Therapies
High-risk stage 1 and 2 NSCLC

 
Modality 1-year 2-year 3-year 5-year LC DM
 
Zemlyak et al SLR (25)
 

 
87.1%
 
12% 12% 3-y cancer-specific 

90.6%, 87.5%, 90.2%

3-y cancer-free (p > 0.05)

60.8%, 50%, 45.6%
RFA (12)
 

 
87.5%
 
33% 25%
PCT (27)
 

 
77.0%
 
11% 7.4%
Kim et al Surgery (14) 93% 77%
 
67% 28.6% 42.9% p = 0.054

Stage 1
RFA (8) 88% 50%
 
25% 50% 37.5
Lee et al Surgery (13) 85.7% 70.1%
 
0%
 

 
p = 0.426

Stage 1 and 2
RFA (16) 100% 76.9%
 
18.7%
 

 
Zemlyak et al. J Am Coll Surg 2010; 211 68-72.
Kim et al. Eur J Radiol 2011; Feb 8 epub ahead of print.
Lee et al. Cardiovasc Intervent Radiol 2011; May 28 epub ahead of print.

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