RF Ablation Results
Pulmonary RFA: Long-term safety and efficacy in 153 patients1
- Local control group (n = 132)
- 71 patients with stage I NSCLC
- Overall survival rates: stage I NSCLC
|
78%
|
57%
|
36%
|
27%
|
27%
|
|
1-year
|
2-year
|
3-year
|
4-year
|
5-year
|
Median time to death = 29 months 95% CI: 20 - 38 months
- Local tumor progression-free rates: ≤ 3 cm vs. > 3 cm
|
≤3cm |
83%
|
64%
|
57%
|
47%
|
47%
|
|
|
1-year
|
2-year
|
3-year
|
4-year
|
5-year
|
|
＞3cm |
45%
|
25%
|
25%
|
25%
|
25%
|
≤ 3 cm: Median time to progression = 45 months
> 3 cm: Median time to progression = 12 months
RF Ablation Results: Comparative Therapies
|
Modality
|
5-year survival
Stage I NSCLC
|
Local Recurrence
(most within 2 years)
|
|
Lobar resection
|
60-80% 能手术尽手术
|
6.4%
|
|
Sub-lobar resection
|
60-70%
|
17.2%
|
|
Image-guided ablation
|
27%
|
22.2%1
|
|
External beam radiation
|
5-20% 外照射I期不好？
|
50-55%
|
1Chan et al. J Thorac Imaging 2011; 26:18-26.
RF Ablation Results: Comparative Therapies
|
Modality
|
5-year survival
Stage I NSCLC
|
Local Recurrence
(most within 2 years)
|
|
Image-guided ablation
|
27%
|
22.2%
|
|
Stereotactic radiotherapy1
|
54%
能放疗尽放疗
|
4%
|
|
Stereotactic radiotherapy2
|
≤ 20 mm 89.8%
> 20 mm 53.1%
|
3.4%
5.3%
|
1Uematsu et al. Int J Radiat Oncol Biol Phys 2008; 72(1):supplement s37.
2Inoue et al. Int J Radiat Oncol Biol Phys 2009 Feb 19.
RF Ablation Results: Comparative Therapies
High-risk stage 1 and 2 NSCLC
|
Modality |
1-year |
2-year |
3-year |
5-year |
LC |
DM |
|
|
Zemlyak et al |
SLR (25) |
|
|
87.1% |
|
12% |
12% |
3-y cancer-specific
90.6%, 87.5%, 90.2%
3-y cancer-free (p > 0.05)
60.8%, 50%, 45.6% |
|
RFA (12) |
|
|
87.5% |
|
33% |
25% |
|
PCT (27) |
|
|
77.0% |
|
11% |
7.4% |
|
Kim et al |
Surgery (14) |
93% |
77% |
|
67% |
28.6% |
42.9% |
p = 0.054
Stage 1 |
|
RFA (8) |
88% |
50% |
|
25% |
50% |
37.5 |
|
Lee et al |
Surgery (13) |
85.7% |
70.1% |
|
0% |
|
|
p = 0.426
Stage 1 and 2 |
|
RFA (16) |
100% |
76.9% |
|
18.7% |
|
|
Zemlyak et al. J Am Coll Surg 2010; 211 68-72.
Kim et al. Eur J Radiol 2011; Feb 8 epub ahead of print.
Lee et al. Cardiovasc Intervent Radiol 2011; May 28 epub ahead of print.
| 