关于局部治疗的肿瘤刺激作用的重大问题仍然存在,其中包括: (a) 当这些影响发生基于器官、肿瘤类型、IO治疗和管理的细节以及介入治疗后后续作用的时间;when these effects occur on the basis of organ, tumor type, specifics of IO therapy and administr...
Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma (HCC). 热消融治疗是局部肝细胞癌(HCC)的标准治疗方法。 In addition to local tumor destruction, ablation leads to abscopal effects in distant lesions mo...
正在努力通过几项人类临床研究,更好地了解栓塞和消融对免疫系统的影响。 大多数这些研究都评估了外周血淋巴细胞种群的变化。 热消融术后,外周血(97)中的CD8T细胞分数增加10%,CD8-Treg比率增加15%。这些变化在加热消融和冷却消融中最为明显。早期乳腺癌...
1. 无论我们在研究和将免疫肿瘤学纳入介入肿瘤学(IO)实践中面临什么挑战,免疫疗法注定会成为IO的一部分。 2. 整合对IO的未来至关重要。将需要采取逻辑步骤来逐步实施和将这一不断发展的领域纳入肿瘤介入放射学的实践。 3. 临床前和临床研究都已经在进行中,...
冷冻消融 Cryoablation Preserves intracellular contents via cell death by necrosis (冷冻)通过使细胞因坏死/死亡来保存细胞内内容物 Intracellular contents (Damage Associated Molecular Patterns DAMPs) will be fagocytized by antigen presenting...
Interventional oncology (IO) is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance...
肝癌 Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma (HCC). 热消融治疗是局部肝细胞癌(HCC)的标准治疗方法。 In addition to local tumor destruction, ablation leads to abscopal effects in distant lesio...
评估肿瘤对免疫治疗的反应,开始在癌症患者的临床治疗中发挥正常作用,对免疫系统相关元素的成像也将至关重要。 目前正在开发几种成像方法来捕获肿瘤微环境的临床相关元素,包括 1. 免疫系统,如生物传感器对冗余的移位偏差的成像和磷光31Mr光谱学(133)。...
Yttrium90(90Y)经动脉放射栓塞(TARE)(也称为选择性内放射治疗)已成为治疗HCC(36-40)和其他癌症(41-45)的常用方法。电离辐射的抗肿瘤作用在很大程度上归因于它通过癌细胞(46)的直接DNA损伤来诱导肿瘤细胞死亡的能力。 除了其局部抗癌功效外,电离辐...
At present, the largest application of transarterial chemoembolization (TACE) of tumors is for hepatocellular carcinoma (HCC). Several lines of evidence support a role for targeting the immune system in HCC. Patients with HCC exhibit a 66%...